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Activity:

Management of Metastatic Melanoma: New Challenges Relative to Tumor Response to Targeted and Immunotherapy: Tumor Mutational Evolution and Eventual "Resistance" to Therapy

Featured Topic Information:
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Continuing Medical Education Information

Date of Original Release: April 4, 2012
Expiration Date: April 4, 2013
Date of last review: April 3, 2012

Presenter:

Antoni Ribas, MD, PhD
Professor of Medicine
Professor of Surgery
Professor of Molecular & Medical Pharmacology
University of California Los Angeles
Director, Tumor Immunology Program
Jonsson Comprehensive Cancer Center
Chair, Melanoma Committee at SWOG
Los Angeles, CA

Instructions For Participation

  • View the video presentation.
  • Complete the posttest and evaluation form that follows the presentation, and then click "submit."
  • You must answer 70% of the posttest questions correctly to earn credit. You will have unlimited opportunities to successfully complete the activity.

To receive a maximum of 0.50 AMA PRA Category 1 Credits™ for this activity:

    • CME Course # 3756
  • 70% of your posttest answers must be correct for you to receive a certificate of credit

To receive up to 0.50 CNE credits for this activity:

  • Within 4 weeks of successful completion, a certificate will be mailed to the address provided
    • CNE Course # 3781
  • 70% of your posttest answers must be correct for you to receive a certificate of credit

Target Audience

This activity is directed toward surgical oncologists, general surgeons, oncology nurses, medical oncologists, dermatologists, and other healthcare professionals who treat or screen for melanoma.

Statement Of Need

Melanoma kills 1 person every hour in the United States. It is a devastating disease with a rising incidence. Melanoma is the most common cancer in women age 25 to 29, is the number one cancer killer of women age 30 to 35, and takes the greatest toll of all cancers on women and men in terms of average years of life lost, because it afflicts young patients to such a great extent.

Management of melanoma remains challenging for all members of the health care team. Assessing risk, getting patients into the healthcare system, evaluating prognostic information, choosing appropriate therapy, working as a team, and educating, guiding and motivating the patient remain challenging. While many healthcare providers are exposed to patients with the potential for melanoma, a core group of specialists are most knowledgeable about the optimal management of this malignancy. These specialists will be the ones to interpret the new information gathered from ongoing research and studies, and to provide suggestions on how to incorporate new treatments into existing disease management algorithms.

Learning Objectives

Upon proper completion of this activity, participants should be better able to:

  • Explain the new immunotherapy and targeted treatments available for metastatic melanoma.
  • Identify the oncogenic mutations involved in metastatic melanoma.
  • Describe the BRAF pathway and possible mechanisms of resistance to BRAF inhibition.

For reading resources related to this activity, click here

Accreditation And Credit Designation

The University of Pittsburgh School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The University of Pittsburgh School of Medicine designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Each physician should claim only the credit commensurate with the extent their participation in the activity.

0.50 contact hours of Continuing Nursing Education will be granted by The University of Pittsburgh Medical Center (UPMC). UPMC is an approved provider of continuing nursing education by the Pennsylvania State Nurses Association (PSNA), an accredited approver by the American Nurses Credentialing Center's Commission on Accreditation.

Disclosure Of Commercial Support

We gratefully acknowledge an educational grant from Bristol-Myers Squibb and Merck in support of this activity.

Contributing Faculty & Disclosures

In accordance with Accreditation Council for Continuing Medical Education requirements on disclosure, faculty and contributors are asked to disclose any relationships with commercial interests associated with the area of medicine featured in the activity. These relationships are described below.

John M. Kirkwood, MD (Chair)
Director, Melanoma and Skin Cancer Program
University of Pittsburgh Cancer Institute
Professor of Medicine, Dermatology and Translational Science
University of Pittsburgh School of Medicine
Pittsburgh, PA
Research Support: Prometheus
Speaker's Bureau: Merck
Consultant: GlaxoSmithKline
SAB participant: Novartis

Antoni Ribas, MD, PhD
Professor of Medicine
Professor of Surgery
Professor of Molecular & Medical Pharmacology
University of California Los Angeles
Director, Tumor Immunology Program
Jonsson Comprehensive Cancer Center
Chair, Melanoma Committee at SWOG
Los Angeles, CA
Consultant: Amgen, Celgene, Genentech, GlaxoSmithKline and Millennium

UPMC Center for Continuing Education in the Health Sciences/Melanoma Care, LLC staff members have no financial conflicts to disclose.

Independent peer reviewer has no financial conflicts to disclose.

Melanoma Care, LLC.
523 Route 303
Orangeburg, NY 10962

© Melanoma Care, 2012, except where noted. This webcast may not be reproduced in whole or part without the express written permission of Melanoma Care, LLC.

This CME program represents the views and opinions of the individual faculty for each case and does not constitute the opinion or endorsement of the editors, the advisory board, the publishing staff, Melanoma Care, the UPMC Center for Continuing Education in the Health Sciences, UPMC/University of Pittsburgh Medical Center or affiliates, or University of Pittsburgh School of Medicine.

Reasonable efforts have been taken to present educational subject matter in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each activity participant must always use his or her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions, including without limitation, FDA-approved uses, and any off-label uses.